Everything You Need To Know About the Amniotic Membrane Can be Found Right Here


A constantly expanding range of ophthalmic diseases are currently being treated using Amniotic Membrane transplantation. It has attracted a lot of attention since it is a successful technique for reconstructing the ocular surface. Epithelial cell migration, basal cellular adhesion, and epithelial differentiation are all made easier by the particular combination of characteristics found in Amniotic Membran. Its usage as a supplement to limbal stem cell transplants for the treatment of ocular surface pathology is a result of its capacity to modify stromal scarring and its anti-inflammatory action.

When partial limbal stem cell shortage, bullous keratopathy, corneoscleral ulcers, and chronic epithelial abnormalities are present, Amniotic Membrane transplantation has been used to restore the corneal surface. In cases of complete limbal stem cell shortage, it has also been utilised in conjunction with limbal stem cell transplantation. Following the removal of pterygia, conjunctival lesions, and symblephara, Amniotic Membran grafts have been successfully used to reconstruct conjunctival defects.

The global Amniotic Membrane Market is estimated to be valued at US$ 3,201.1 Mn in 2021, and is expected to exhibit a CAGR of 12.8% over the forecast period (2021-2028).

The term "Amniotic Membrane" refers to the placenta's innermost region that is in contact with the foetus directly (Amnio-M). The Amnio-M is made up of three layers: a stroma, a foundation membrane, and an epithelial layer facing the foetus. The latter is made up of three layers: a compact layer, a fibroblast layer, and an outer, spongy layer. Amniotic epithelial cells (AECs) and amniotic mesenchymal stromal cells are the two types of cells that make up these layers (AMSCs). By producing extracellular matrix (ECM) and supplying various cytokines and growth factors, cells of the amnio-M are crucial for controlling the development of the embryo. Numerous instances in the literature describe the application of human Amniotic Membran, which was removed from the placenta during a caesarean section and kept until use, to the surface of the eye. Amniotic 

Membran that has been cryopreserved can be surgically affixed to the ocular surface using absorbable or non-absorbable sutures, and it retains the histological and morphological characteristics of fresh tissue. Amniotic Membran has also been affixed to the ocular surface using biological tissue adhesives.

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