Hepatocellular Carcinoma Drugs Are Becoming Highly Efficient Treatment


Hepatocellular Carcinoma drugs are used to treat hepatocellular carcinoma, which is a type of cancer that starts in the liver. It can also spread to other parts of the body (metastatic disease). This type of cancer develops in the liver (liver cells). It's more common in people with cirrhosis, a scarring of the liver from previous damage. It's also more common in people who have chronic infections with the hepatitis B or C viruses or who have had fatty liver disease or alcohol use problems for long periods of time.

Hepatitis B virus infection can increase the risk of hepatocellular carcinoma by more than 100 times, and it is a common cause of liver cancer in many countries, especially in Africa and Asia. Vaccines that protect against hepatitis B can also help reduce the chance of getting hepatocellular carcinoma. Hepatitis B and hepatitis C are often associated with hepatocellular carcinoma, as are obesity, diabetes and alcohol abuse. Hepatocellular carcinoma is most common in people who have cirrhosis caused by hepatitis B or hepatitis C infection. Sorafenib is one of the Hepatocellular Carcinoma drugs, which is a multikinase inhibitor that blocks the activity of several receptors involved in cell proliferation and angiogenesis, including RAF-1, BRAF, VEGFRs, PDGFR and KIT. It has been the standard first-line treatment for people with advanced HCC since the FDA approved it in 2007. Sorafenib is sometimes given in combination with other drugs, such as lenvatinib or cabozantinib.

According to Coherent Market Insights the Hepatocellular Carcinoma Drugs Market Industry Insights, Trends, Outlook, and Opportunity Analysis, 2022-2028.

Another hepatocellular carcinoma drug that targets these receptors is a tyrosine kinase inhibitor called regorafenib, which was FDA-approved for the treatment of patients with advanced hepatocellular carcinoma in 2017. It works by blocking the action of tyrosine kinases on tumor growth and angiogenesis. Other anti-tumor hepatocellular carcinoma drug that attack the receptors are adalimumab and elotuzumab, both of which have been approved by the FDA for the treatment of HCC. Adalimumab and elotuzumab work by targeting the protein ALK, which helps cancer cells grow and survive.

Immunotherapy and cytotoxic chemotherapy are other types of hepatocellular carcinoma drugs that attack the receptors and enzymes in the body that help the tumor grow. These drugs can be injected, put in a liquid form or given through a tube in the mouth or throat. These drugs can cause side effects, which are things that make it hard for patients to do everyday things or feel good. They can include nausea, vomiting and a loss of appetite. In October 2022, AstraZeneca received approval from the U.S. Food and Drug Administration for Imjudo(tremelimumab) plus Imfinzi (durvalumab), designed for treating unresectable hepatocellular carcinoma in adults


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